Cannabis and Cannabinoids

Although the supply and possession of cannabis is unlawful in most countries, it is estimated that over 1% of MS patients take it. Cannabis is mainly used for muscle spasm and the pain associated with it.

Effectiveness

Some trials with the psychoactive component, THC, have shown it is effective in certain patients in reducing spasm and chronic pain. However, a recent study in Holland on 16 patients with progressive MS showed that neither the plant extract nor THC capsules were move effective than placebo. The authors did say that their results may have been affected by the way that the drug was administered (swallowed instead of smoked).

Effect on memory

Another recent study in the USA, showed that heavy use of marijuana is associated with a significant reduction in cognitive function (mainly memory) even 28 days after smoking the last joint.

Future work

There are ongoing studies on the use of cannabinoids in MS and these will be used by the government as the basis for a decision on licensing these products for prescription.

Reference:

Bolla KI et al. Dose-related neurocognitive effects of marijuana use. Neurology 2002; 59: 1337-1343. Williamson EM and Evans FJ. Cannabinoids in clinical practice. Drugs 2000; 60(6): 1303-1314.