MS and infections
Administrative data suggest that infection-related health care utilization is generally greater for patients with MS across all age groups compared with the general population [1-4].
For instance, data collected between 1996 and 2013 in British Columbia, Canada (7,179 MS cases and 35,837 controls) showed that, relative to controls, MS patients :
- were over twice as likely to be hospitalized for infection (aOR: 2.39, 95% CI: 2.16-2.65)
- had 41% more infection-related physician visits (aRR: 1.41, 95% CI: 1.36-1.47)
- filled 57% more infection-related prescriptions* (aRR: 1.57, 95% CI: 1.49-1.65).
According to this study and another Canadian Claims data evaluation, typical infections triggering health care utilization in MS patients were pneumonia [2,3], influenza , urinary tract infections [2,3], pressure ulcers [2,3] and sepsis . Health care utilization due to upper respiratory tract infections was also high, but remained in the same range for people with MS and controls .
Older age, male sex, worse physical disability, and lower socioeconomic status were associated with increased infection-related hospitalization rates in MS . Other evaluations report that exposure to immunosuppressive therapies increases the risk for infectious complications in patients with MS [5-7].
*included antimicrobials for oral or parenteral use, including antibiotics, antivirals, or antimycotics.
- Brownlee W et al. Neurology 2020; 94(22): 949-52. Return to content
- Wijnands JMA et al. Mult Scler 2017; 23(11): 1506-16. Return to content
- Marrie RA et al. Neurology 2014; 83(10): 929-37. Return to content
- Montgomery S et al. Europ J Neurol 2013; 20(8): 1153-60. Return to content
- Reyes S et al. J Neuroimmunol 2021; 357: 577627. Return to content
- Reyes S et al. Pract Neurol 2020; 20(6): 435-45. Return to content
- Epstein DJ et al. Open Forum Infect Dis 2018; 5(8): ofy174. Return to content