Insights into ageing processes
Ageing is a gradual and progressive deterioration of integrity across the body . With age, wrinkles appear, the stomach sags and the hair goes gray . Increasing age may also mean a higher likelihood of immunosenescence age-related changes to the immune system, less biological reserve, and co-morbidities [3,4]. Since not everyone ages at the same rate, chronological and biological ages may be different .
Patients with MS seem to be susceptible to accelerated biological ageing [5-7] and so may be ‘older’ than their years . For instance, a study from Germany found shorter telomere length (a marker of biological ageing) in people with MS compared with healthy controls across all stages of the disease .
Factors that may contribute to this accelerated ageing in MS include:
- immunosenescence [3,4,6]
- co-morbidities [8,9]
- lifestyle factors [10,11].
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